Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Akr1b1tm1Skc
Name:	aldo-keto reductase family 1 member B; targeted mutation 1, Sookja K Chung
MGI ID:	MGI:2183239
Synonyms:	Aldor1-, AR-, AR-KO
Gene:	Akr1b1  Location: Chr6:34280865-34294424 bp, - strand  Genetic Position: Chr6, 14.87 cM, cytoband B1
Alliance:	Akr1b1tm1Skc page

Germline Transmission:	Earliest citation of germline transmission: J:77647
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 2.7kb of sequence, encompassing a portion of exon 5 and all of exons 6, 7, and 8, was replaced by a neomycin selection cassette. The absence of transcript and protein in homozygous mutant mice was determined via Northern blot and Western blot analyses of various tissues. (J:77647)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akr1b1 Mutation:	27 strains or lines available

Original:	J:77647 Ho HT, et al., Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. Mol Cell Biol. 2000 Aug;20(16):5840-6
All:	20 reference(s)