Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfrsf11btm1Wss
Name:	tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin); targeted mutation 1, W Scott Simonet
MGI ID:	MGI:2183229
Synonyms:	OPG-
Gene:	Tnfrsf11b  Location: Chr15:54114014-54141700 bp, - strand  Genetic Position: Chr15, 21.15 cM
Alliance:	Tnfrsf11btm1Wss page

Germline Transmission:	Earliest citation of germline transmission: J:47602
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette into exon 2 replaced sequence encoded the first 93 residues of the mature protein. This targeting strategy eliminated the first two cysteine-rich domains, which are essential for function, and introduced an in-frame stop codon. Northern blot analysis of total hepatic RNA confirmed the absence of transcript in homozygous mutant mice. (J:47602)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf11b Mutation:	29 strains or lines available

Original:	J:47602 Bucay N, et al., osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 1998 May 1;12(9):1260-8
All:	7 reference(s)