Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfrsf11atm1Wjb
Name:	tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1, William J Boyle
MGI ID:	MGI:2183226
Synonyms:	RANK-
Gene:	Tnfrsf11a  Location: Chr1:105708443-105775709 bp, + strand  Genetic Position: Chr1, 49.7 cM
Alliance:	Tnfrsf11atm1Wjb page

Germline Transmission:	Earliest citation of germline transmission: J:77636
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 2 and all of exon 3 was replaced with a neomycin selection cassette. The deleted region encoded approximately one and one half of the amino-terminal TNFR-like cysteine-rich domain, comprised of residues 34 through 96. Northern blot analysis confirmed the absence of normal transcript, while the results of a Western blot analysis of intestinal lysates using antibodies raised against the extracellular domain of the endogenous protien indicated a lack of protein. (J:77636)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf11a Mutation:	42 strains or lines available

Original:	J:77636 Li J, et al., RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1566-71
All:	6 reference(s)