Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Ucp3tm1Rei
Name:	uncoupling protein 3 (mitochondrial, proton carrier); targeted mutation 1, Marc L Reitman
MGI ID:	MGI:2183202
Synonyms:	Ucp3 (-)
Gene:	Ucp3  Location: Chr7:100122198-100135639 bp, + strand  Genetic Position: Chr7, 54.36 cM
Alliance:	Ucp3tm1Rei page

Germline Transmission:	Earliest citation of germline transmission: J:62312
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 4.0 kb of sequence, including the first coding exon (exon 2), was deleted and replaced with a neomycin selection cassette. Northern blot and RT-PCR analyses detected aberrantly spliced transcript, in which exon 1 had spliced directly to exon 3, in homozygous mutant mice. Protein encoded from the aberrant transcript was undetected via Western blot analysis. (J:62312)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Ucp3tm1Rei

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ucp3 Mutation:	4 strains or lines available

Original:	J:62312 Gong DW, et al., Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem. 2000 May 26;275(21):16251-7
All:	19 reference(s)