Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tectatm1Gpr
Name:	tectorin alpha; targeted mutation 1, Guy P Richardson
MGI ID:	MGI:2183148
Synonyms:	TectadeltaENT
Gene:	Tecta  Location: Chr9:42240915-42311225 bp, - strand  Genetic Position: Chr9, 23.63 cM
Alliance:	Tectatm1Gpr page

Germline Transmission:	Earliest citation of germline transmission: J:77634
Parent Cell Line:	CCB (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The insertion of a neomycin selection cassette disrupted exon 3. RT-PCR and sequence analysis of mutant mice revealed that the insertion of the neo cassette resulted in exon skipping, producing a transcript in which exons 2 and 4 are joined. While, encoded protein was undetected in homozygous mutant mice via Western blot analysis, immunofluorescence analysis showed immunoreactivity in the greater epithelial ridge and in isolated spots in the tectorial membrane. (J:77634)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tecta Mutation:	133 strains or lines available

Original:	J:77634 Legan PK, et al., A targeted deletion in alpha-tectorin reveals that the tectorial membrane is required for the gain and timing of cochlear feedback. Neuron. 2000 Oct;28(1):273-85
All:	8 reference(s)