Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnfrsf21tm1Ddy
Name:	tumor necrosis factor receptor superfamily, member 21; targeted mutation 1, Derek D Yang
MGI ID:	MGI:2182829
Synonyms:	DR6-
Gene:	Tnfrsf21  Location: Chr17:43327446-43400079 bp, + strand  Genetic Position: Chr17, 19.69 cM, cytoband C
Alliance:	Tnfrsf21tm1Ddy page

Germline Transmission:	Earliest citation of germline transmission: J:70594
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 and 3, which include the translation initiation site, were replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was demonstrated by Northern blot analysis of kidney RNA using a cDNA probe to exon 4. (J:70594)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf21 Mutation:	61 strains or lines available

Original:	J:70594 Liu J, et al., Enhanced CD4+ T cell proliferation and Th2 cytokine production in DR6-deficient mice. Immunity. 2001 Jul;15(1):23-34
All:	3 reference(s)