Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ets1tm2Jml
Name:	E26 avian leukemia oncogene 1, 5' domain; targeted mutation 2, Jeffrey M Leiden
MGI ID:	MGI:2182780
Synonyms:	Ets-1-, Ets1 KO
Gene:	Ets1  Location: Chr9:32547517-32669116 bp, + strand  Genetic Position: Chr9, 17.97 cM
Alliance:	Ets1tm2Jml page

Germline Transmission:	Earliest citation of germline transmission: J:50627
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A region encompassing all of exon 3 and a portion of exon 4 was deleted by the insertion of a neomycin selection cassette. Neither normal nor truncated protein was detected via Western blot analysis of splenocyte protein extracts obtained from homozygous mutant mice. (J:50627)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ets1 Mutation:	25 strains or lines available

Original:	J:50627 Barton K, et al., The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity. 1998 Oct;9(4):555-63
All:	23 reference(s)