Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nfatc3tm1Glm
Name:	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3; targeted mutation 1, Laurie H Glimcher
MGI ID:	MGI:2182778
Synonyms:	c3-, c3-KO, NFAT4-, nfatc3-, Nfatc4 -
Gene:	Nfatc3  Location: Chr8:106785472-106857169 bp, + strand  Genetic Position: Chr8, 53.08 cM, cytoband D
Alliance:	Nfatc3tm1Glm page

Germline Transmission:	Earliest citation of germline transmission: J:50124
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encoding the DNA-binding domain, encoding amino acids 535 through 592, was replaced with a neomycin selection cassette. Encoded protein was undetected via Western blot analysis of thymus protein extracts obtained from homozygous mutant mice. (J:50124)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfatc3 Mutation:	70 strains or lines available

Original:	J:50124 Oukka M, et al., The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity. 1998 Sep;9(3):295-304
All:	38 reference(s)