Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Mzf1tm1Ppp
Name:	myeloid zinc finger 1; targeted mutation 1, Pier Paolo Pandolfi
MGI ID:	MGI:2182764
Synonyms:	Mzf1-
Gene:	Mzf1  Location: Chr7:12776230-12788691 bp, - strand  Genetic Position: Chr7, 7.73 cM
Alliance:	Mzf1tm1Ppp page

Germline Transmission:	Earliest citation of germline transmission: J:70407
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of the coding region of the gene containing the DNA-binding domain and the first 11 zinc finger domains was replaced with a PGK-neo cassette in the opposite orientation via homologous recombination. Homozygous mutant animals lacked gene expression as shown by RT-PCR analysis of bone marrow cells. (J:70407)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Mzf1tm1Ppp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mzf1 Mutation:	40 strains or lines available

Original:	J:70407 Gaboli M, et al., Mzf1 controls cell proliferation and tumorigenesis. Genes Dev. 2001 Jul 1;15(13):1625-30
All:	1 reference(s)