Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rnaseltm1Slvm
Name:	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent); targeted mutation 1, Robert H Silverman
MGI ID:	MGI:2182763
Synonyms:	RL-, RNase L-, Rnaselem1Cya
Gene:	Rnasel  Location: Chr1:153625172-153639967 bp, + strand  Genetic Position: Chr1, 65.43 cM, cytoband G2
Alliance:	Rnaseltm1Slvm page

Germline Transmission:	Earliest citation of germline transmission: J:44292
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 1, encoding the activator-binding region, was disrupted at codon 100 by the insertion of a neomycin selection cassette. The absence of normal protein in homozygous mutant mice was determined via Western blot analysis of MEF protein extracts and by binding assays on extracts from various organs. No ribonuclease activity was detected in MEF via Northern blot analysis. (J:44292)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rnasel Mutation:	26 strains or lines available

Original:	J:44292 Zhou A, et al., Interferon action and apoptosis are defective in mice devoid of 2',5'-oligoadenylate-dependent RNase L. EMBO J. 1997 Nov 3;16(21):6355-63
All:	31 reference(s)