Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Festm2Mcs
Name:	feline sarcoma oncogene; targeted mutation 2, M Celeste Simon
MGI ID:	MGI:2182589
Synonyms:	c-fesdeltac
Gene:	Fes  Location: Chr7:80027504-80037694 bp, - strand  Genetic Position: Chr7, 45.65 cM
Alliance:	Festm2Mcs page

Mouse Generated:	Earliest citation of chimera generation: J:76509
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 2.5 kb region of the gene spanning exons 12-14 were replaced with a PGK-neo cassette via homologous recombination. The gene targeting event results in deletion of the C-terminal SH2 domain and the ATP-binding site of the tyrosine kinase domain (amino acids 497-607). Homozygous mutant embryonic stem cells were identified via Southern blot analysis. (J:76509)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fes Mutation:	40 strains or lines available

Original:	J:76509 Hackenmiller R, et al., Truncation of c-fes via gene targeting results in embryonic lethality and hyperproliferation of hematopoietic cells. Dev Biol. 2002 May 15;245(2):255-69
All:	1 reference(s)