Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Itgb8tm1Lfr
Name:	integrin beta 8; targeted mutation 1, Louis F Reichardt
MGI ID:	MGI:2182548
Synonyms:	beta8-
Gene:	Itgb8  Location: Chr12:119121757-119202537 bp, - strand  Genetic Position: Chr12, 63.48 cM
Alliance:	Itgb8tm1Lfr page

Germline Transmission:	Earliest citation of germline transmission: J:77682
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neo-cassette replaced sequences encoding 45 amino acids at the C-terminus, corresponding to exon 4, which includes a von Willebreand factor-A-like domain, and part of the intron sequences. This targeting event resulted in a frameshift in addition to a deletion, abolishing functional Itgb8 protein. Northern blot and RT-PCR analysis verified the lack of functional transcript in homozygous mice. (J:77682)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb8 Mutation:	44 strains or lines available

Original:	J:77682 Zhu J, et al., beta8 integrins are required for vascular morphogenesis in mouse embryos. Development. 2002 Jun;129(12):2891-903
All:	20 reference(s)