Brca1tm2.1Cxd
Targeted Allele Detail
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Symbol: |
Brca1tm2.1Cxd |
Name: |
breast cancer 1, early onset; targeted mutation 2.1, Chu-Xia Deng |
MGI ID: |
MGI:2182470 |
Synonyms: |
Brca1delta11, Brca1deltaexon11, Brcadelta11 |
Gene: |
Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
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Alliance: |
Brca1tm2.1Cxd page
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Exencephaly and growth retardation in Brca1tm2.1Cxd/Brca1tm2.1Cxd Gadd45atm1Ajf/Gadd45atm1Ajf embryos
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:70271
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Parent Cell Line: |
TC1/TC-1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: This allele, lacking exon 11, was generated by crossing mice heterozygous for Brca1tm2Cxd with transgenic mice expressing the cre recombinase gene via the EIIa promoter which is active in germ cells. Northern blot analysis of homozygous mutant embryos indicated an absence of full length transcript. Transcript lacking exon 11 was detected in both wild-type and mutant embryos, though the levels were increased in homozygous mutant embyros.
(J:70271)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:70271 Xu X, et al., Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001 Jul;28(3):266-71 |
All: |
29 reference(s) |
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