Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cyp24a1tm1Star
Name:	cytochrome P450, family 24, subfamily a, polypeptide 1; targeted mutation 1, Rene St-Arnaud
MGI ID:	MGI:2182338
Synonyms:	24-OHase
Gene:	Cyp24a1  Location: Chr2:170324877-170339065 bp, - strand  Genetic Position: Chr2, 91.91 cM
Alliance:	Cyp24a1tm1Star page

Germline Transmission:	Earliest citation of germline transmission: J:56453
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 9 and 10, the latter encoding the heme-binding domain, were replaced with a PGK-neo selection cassette. Transcript was reported to be undetectable in homozygous mutant mice. Neither an immunoassay nor HPLC fractionation followed by a competitive binding assay could detect the enzymatic product, 24,25-dihydroxyvitamin D, of the encoded protein in homozygous mutant mice. (J:63457)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp24a1 Mutation:	28 strains or lines available

Original:	J:56453 St-Arnaud R, Targeted inactivation of vitamin D hydroxylases in mice. Bone. 1999 Jul;25(1):127-9
All:	7 reference(s)