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Cables2 Gene Detail
Summary
  • Symbol
    Cables2
  • Name
    CDK5 and Abl enzyme substrate 2
  • Synonyms
    ik3-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182335
    NCBI Gene: 252966
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:179900332-179915258 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 102.78 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    41 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182335
 protein coding gene Chr2:179900332-179915289 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026991
 protein coding gene Chr2:186773650-186789341 (-)
A/J MGP_AJ_G0026957
 protein coding gene Chr2:179096317-179112916 (-)
AKR/J MGP_AKRJ_G0026927
 protein coding gene Chr2:184460637-184482210 (-)
BALB/cJ MGP_BALBcJ_G0026966
 protein coding gene Chr2:179557909-179577266 (-)
C3H/HeJ MGP_C3HHeJ_G0026707
 protein coding gene Chr2:184807613-184824388 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027412
 protein coding gene Chr2:192161951-192176115 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024778
 protein coding gene Chr2:169785379-169802444 (-)
CAST/EiJ MGP_CASTEiJ_G0026166
 protein coding gene Chr2:183056166-183071537 (-)
CBA/J MGP_CBAJ_G0026684
 protein coding gene Chr2:199159124-199174622 (-)
DBA/2J MGP_DBA2J_G0026822
 protein coding gene Chr2:178197399-178212355 (-)
FVB/NJ MGP_FVBNJ_G0026788
 protein coding gene Chr2:176802105-176818804 (-)
LP/J MGP_LPJ_G0026923
 protein coding gene Chr2:186767700-186787720 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026807
 protein coding gene Chr2:201770346-201789062 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027471
 protein coding gene Chr2:184420415-184438492 (-)
PWK/PhJ MGP_PWKPhJ_G0025902
 protein coding gene Chr2:175706251-175721769 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025702
 protein coding gene Chr2:180917002-180935639 (-)
WSB/EiJ MGP_WSBEiJ_G0026238
 protein coding gene Chr2:185388262-185418204 (-)



Homology
more
  • Human Ortholog
    CABLES2, Cdk5 and Abl enzyme substrate 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CABLES2, Cdk5 and Abl enzyme substrate 2
  • Synonyms
    C20orf150, dJ908M14.2, ik3-2
  • Links
    NCBI Gene ID: 81928
    neXtProt AC: NX_Q9BTV7
    UniProt: Q9BTV7

  • Chr Location
    20q13.33; chr20:62388634-62407285 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a null allele that impacts Rps21 expression produces embryonic lethality during organogenesis, decreased body size, and growth arrest. Mice homozygous for a null allele that does not impact Rps21 expression are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

Biological Process

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 252966 NCBI Gene Model | MGI Sequence Detail 14927 C57BL/6J ±  kb
    transcript NR_177232 RefSeq | MGI Sequence Detail 2974 C57BL/6  
    polypeptide Q8K3M5 UniProt | EBI | MGI Sequence Detail 476 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 60

      Microarray probesets 3
    References
    more
    • Summaries
      All 24
      Gene Ontology 3
      Phenotypes 5
    • Earliest
      J:76235 Sato H, et al., ik3-2, a relative to ik3-1/Cables, is associated with cdk3, cdk5, and c-abl. Biochim Biophys Acta. 2002 Mar 19;1574(2):157-63
    • Latest
      J:309963 Dinh TTH, et al., Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Elife. 2021 May 5;10:e50346
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory