Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nkx6-2tm1Qiu
Name:	NK6 homeobox 2; targeted mutation 1, Mengsheng Qiu
MGI ID:	MGI:2182286
Synonyms:	Nkx6.2-
Gene:	Nkx6-2  Location: Chr7:139159292-139162713 bp, - strand  Genetic Position: Chr7, 84.57 cM
Alliance:	Nkx6-2tm1Qiu page

Germline Transmission:	Earliest citation of germline transmission: J:69975
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 1 through 3 were deleted by the insertion of a neomycin selection cassette. RT-PCR analysis and in situ hybridization of embryonic midbrain showed an absence of transcript in homozygous mutant mice. The expression of Nkx6-1 was shown to be unaffected by the targeting event via in situ hybridization. (J:69975)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx6-2 Mutation:	16 strains or lines available

Original:	J:69975 Cai J, et al., Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally. Mol Cell Biol. 2001 Jul;21(13):4399-403
All:	4 reference(s)