Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ctsstm1Hap
Name:	cathepsin S; targeted mutation 1, Harold A Chapman
MGI ID:	MGI:2182133
Synonyms:	catS-
Gene:	Ctss  Location: Chr3:95434097-95463714 bp, + strand  Genetic Position: Chr3, 40.74 cM
Alliance:	Ctsstm1Hap page

Germline Transmission:	Earliest citation of germline transmission: J:53799
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 5, encoding the active site cysteine, was replaced with a neomycin selection cassette. Western blot analysis showed an absence of encoded protein in splenocyte and dendritic cell lysates derived from homozygous mutant mice. (J:53799)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ctss Mutation:	30 strains or lines available

Original:	J:53799 Shi GP, et al., Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity. 1999 Feb;10(2):197-206
All:	44 reference(s)