Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Sox4tm2Cle
Name:	SRY (sex determining region Y)-box 4; targeted mutation 2, Hans Clevers
MGI ID:	MGI:2182108
Synonyms:	Tg2001
Gene:	Sox4  Location: Chr13:29132902-29137682 bp, - strand  Genetic Position: Chr13, 12.87 cM, cytoband A3-A5
Alliance:	Sox4tm2Cle page

Germline Transmission:	Earliest citation of germline transmission: J:32741
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A construct containing a neomycin selection cassette in the opposite orientation and lacking a start codon replaced the 5' region of the gene. Northern blot analysis showed an absence of transcript in the heads of homozygous mutant embryos. (J:32741)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox4 Mutation:	20 strains or lines available

Original:	J:32741 Schilham MW, et al., Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature. 1996 Apr 25;380(6576):711-4
All:	1 reference(s)