Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	n-TUtca2tm1Mmt
Name:	nuclear encoded tRNA selenocysteine 2 (anticodon TCA); targeted mutation 1, Makoto M Taketo
MGI ID:	MGI:2181883
Synonyms:	Trsp (-)
Gene:	n-TUtca2  Location: Chr7:19035169-19035255 bp, + strand  Genetic Position: Chr7, 9.56 cM
Alliance:	n-TUtca2tm1Mmt page

Germline Transmission:	Earliest citation of germline transmission: J:40911
Parent Cell Line:	D3a2 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire gene was replaced with a neomycin selection cassette inserted by homologous recombination. The levels of tRNA in various organs of heterozygous mice were found to be approximately 50 to 80% of those in wild-type mice. (J:40911)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any n-TUtca2 Mutation:	2 strains or lines available

Original:	J:40911 Bosl MR, et al., Early embryonic lethality caused by targeted disruption of the mouse selenocysteine tRNA gene (Trsp). Proc Natl Acad Sci U S A. 1997 May 27;94(11):5531-4
All:	1 reference(s)