Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kcnab1tm1Sva
Name:	potassium voltage-gated channel, shaker-related subfamily, beta member 1; targeted mutation 1, Alcino J Silva
MGI ID:	MGI:2181771
Synonyms:	Kvbeta1.1-deficient
Gene:	Kcnab1  Location: Chr3:64856636-65285643 bp, + strand  Genetic Position: Chr3, 30.15 cM
Alliance:	Kcnab1tm1Sva page

Germline Transmission:	Earliest citation of germline transmission: J:51147
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into codon 25 of exon 1 via homologous recombination. Northern and Western blot analysis of brain from homozygous mutant animals confirmed the absence of gene expression. (J:51147)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Kcnab1 Mutation:	27 strains or lines available

Original:	J:51147 Giese KP, et al., Reduced K+ channel inactivation, spike broadening, and after-hyperpolarization in Kvbeta1.1-deficient mice with impaired learning. Learn Mem. 1998 Sep-Oct;5(4-5):257-73
All:	5 reference(s)