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Il23r Gene Detail
Summary
  • Symbol
    Il23r
  • Name
    interleukin 23 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181693
    NCBI Gene: 209590
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:67399916-67468839 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 30.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    414 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181693
 protein coding gene Chr6:67399906-67468839 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030846
 protein coding gene Chr6:67423947-67506270 (-)
A/J MGP_AJ_G0030816
 protein coding gene Chr6:64526058-64596132 (-)
AKR/J MGP_AKRJ_G0030744
 protein coding gene Chr6:66534649-66608559 (-)
BALB/cJ MGP_BALBcJ_G0030827
 protein coding gene Chr6:64885507-64963933 (-)
C3H/HeJ MGP_C3HHeJ_G0030885
 protein coding gene Chr6:117528542-117607014 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031285
 protein coding gene Chr6:69026743-69114894 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028474
 protein coding gene Chr6:61672259-61740877 (-)
CAST/EiJ MGP_CASTEiJ_G0029935
 protein coding gene Chr6:66826351-66903491 (-)
CBA/J MGP_CBAJ_G0030514
 protein coding gene Chr6:71850524-71934123 (-)
DBA/2J MGP_DBA2J_G0030666
 protein coding gene Chr6:64190168-64258167 (-)
FVB/NJ MGP_FVBNJ_G0030619
 protein coding gene Chr6:63678351-63746056 (-)
LP/J MGP_LPJ_G0030745
 protein coding gene Chr6:67380184-67453823 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030654
 protein coding gene Chr6:75592153-75679511 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031311
 protein coding gene Chr6:66456867-66533743 (-)
PWK/PhJ MGP_PWKPhJ_G0029650
 protein coding gene Chr6:63369882-63443376 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029479
 protein coding gene Chr6:66073666-66149191 (-)
WSB/EiJ MGP_WSBEiJ_G0030017
 protein coding gene Chr6:66787515-66859999 (-)



Homology
more
  • Human Ortholog
    IL23R, interleukin 23 receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL23R, interleukin 23 receptor
  • Synonyms
    PSORS7
  • Links
    NCBI Gene ID: 149233
    neXtProt AC: NX_Q5VWK5
    UniProt: Q5VWK5

  • Chr Location
    1p31.3; chr1:67138637-67265903 (+)  GRCh38
Human Diseases
more
  • Diseases
    19 with human IL23R associations

Human Disease Mouse Models
      
IDs
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 5 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Th17 T cells from homozygous null mice have less secretion of IL-9 upon secondary stimulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049093 Ensembl Gene Model | MGI Sequence Detail 68924 C57BL/6J ±  kb
    transcript ENSMUST00000118364 Ensembl | MGI Sequence Detail 2488 Not Applicable  
    polypeptide ENSMUSP00000113342 Ensembl | MGI Sequence Detail 644 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 126
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 89
    • Earliest
      J:65966 Oppmann B, et al., Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000 Nov;13(5):715-25
    • Latest
      J:343178 Jacobse J, et al., Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells. Cell Rep. 2023 Feb 28;42(2):112128
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory