Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Socs3tm1Jni
Name:	suppressor of cytokine signaling 3; targeted mutation 1, James N Ihle
MGI ID:	MGI:2181439
Synonyms:	SOCS-3 -, SOCS3-, Socs3tm11Jni
Gene:	Socs3  Location: Chr11:117856905-117860192 bp, - strand  Genetic Position: Chr11, 82.96 cM, cytoband E2
Alliance:	Socs3tm1Jni page

Germline Transmission:	Earliest citation of germline transmission: J:57476
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region of the gene was replaced with a neomycin resistance cassette by homologous recombination. Homozygous embryos lacked gene expression as determined by immunofluorescent staining of erythroid progenitor cells. (J:57476)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Socs3 Mutation:	21 strains or lines available

Original:	J:57476 Marine JC, et al., SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell. 1999 Sep 3;98(5):617-27
All:	13 reference(s)