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Slc5a2 Gene Detail
Summary
  • Symbol
    Slc5a2
  • Name
    solute carrier family 5 (sodium/glucose cotransporter), member 2
  • Synonyms
    Sglt2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181411
    NCBI Gene: 246787
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127864855-127871602 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 70.08 cM, cytoband F4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    80 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181411
 protein coding gene Chr7:127864829-127871602 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033080
 protein coding gene Chr7:132681963-132688660 (+)
A/J MGP_AJ_G0033062
 protein coding gene Chr7:129111786-129118374 (+)
AKR/J MGP_AKRJ_G0032994
 protein coding gene Chr7:132486763-132493259 (+)
BALB/cJ MGP_BALBcJ_G0033063
 protein coding gene Chr7:128775521-128782156 (+)
C3H/HeJ MGP_C3HHeJ_G0032777
 protein coding gene Chr7:132375181-132381816 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033573
 protein coding gene Chr7:137855041-137863006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030545
 protein coding gene Chr7:130292790-130299257 (+)
CAST/EiJ MGP_CASTEiJ_G0032107
 protein coding gene Chr7:124163517-124170119 (+)
CBA/J MGP_CBAJ_G0032750
 protein coding gene Chr7:142556708-142566683 (+)
DBA/2J MGP_DBA2J_G0032902
 protein coding gene Chr7:127100045-127106633 (+)
FVB/NJ MGP_FVBNJ_G0032855
 protein coding gene Chr7:126962992-126970185 (+)
LP/J MGP_LPJ_G0032996
 protein coding gene Chr7:134155310-134162092 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032887
 protein coding gene Chr7:143586875-143593474 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033592
 protein coding gene Chr7:131454522-131461157 (+)
PWK/PhJ MGP_PWKPhJ_G0031813
 protein coding gene Chr7:120109526-120116329 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031659
 protein coding gene Chr7:118260195-118268465 (+)
WSB/EiJ MGP_WSBEiJ_G0032218
 protein coding gene Chr7:132429224-132435813 (+)



Homology
more
  • Human Ortholog
    SLC5A2, solute carrier family 5 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC5A2, solute carrier family 5 member 2
  • Synonyms
    SGLT2
  • Links
    NCBI Gene ID: 6524
    neXtProt AC: NX_P31639
    UniProt: P31639

  • Chr Location
    16p11.2; chr16:31483002-31490860 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC5A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 2 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased urine glucose, increased eating and drinking behaviors, increased circulating renin activity, decreased urine osmolality, decreased serum aldosterone levels, polyuria, and decreased glucose renal reabsorption.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    846
  • Tissues
    136
  • cDNA Data
    54
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 246787 NCBI Gene Model | MGI Sequence Detail 6748 C57BL/6J ±  kb
    transcript NM_133254 RefSeq | MGI Sequence Detail 2270 C57BL/6  
    polypeptide Q923I7 UniProt | EBI | MGI Sequence Detail 670 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 54

      Microarray probesets 6
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 19
    • Earliest
      J:35094 Wiley LM, et al., Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol. 1991 Jan;143(1):149-61
    • Latest
      J:334374 Zhao XP, et al., Hedgehog interacting protein activates sodium-glucose cotransporter 2 expression and promotes renal tubular epithelial cell senescence in a mouse model of type 1 diabetes. Diabetologia. 2023 Jan;66(1):223-240
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory