Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Itgaltm1Mak
Name:	integrin alpha L; targeted mutation 1, Tak W Mak
MGI ID:	MGI:2181378
Synonyms:	CD11a -, LFA-1-
Gene:	Itgal  Location: Chr7:126895432-126934310 bp, + strand  Genetic Position: Chr7, 69.44 cM
Alliance:	Itgaltm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:77269
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encoding the signal peptide and the amino terminal extracellular domain (exons 2 through 6) was replaced with a neomycin selection cassette. Surface expression was undetected by FACS analysis of homozygous mutant B and T cells. (J:77269)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Itgal Mutation:	74 strains or lines available

Original:	J:77269 Schmits R, et al., LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J Exp Med. 1996 Apr 1;183(4):1415-26
All:	20 reference(s)