Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hptm1Skl
Name:	haptoglobin; targeted mutation 1, Sai-Kiang Lim
MGI ID:	MGI:2181293
Synonyms:	Hp-, Hp 0
Gene:	Hp  Location: Chr8:110301760-110305804 bp, - strand  Genetic Position: Chr8, 57.11 cM
Alliance:	Hptm1Skl page

Germline Transmission:	Earliest citation of germline transmission: J:49888
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2-4 were replaced with a neomycin resistance gene via homologous recombination. RT-PCR analysis of liver and Western blot analysis of plasma from homozygous mutant animals verified the absence of gene expression from the null allele. (J:49888)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hp Mutation:	13 strains or lines available

Original:	J:49888 Lim SK, et al., Increased susceptibility in Hp knockout mice during acute hemolysis. Blood. 1998 Sep 15;92(6):1870-7
All:	23 reference(s)