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Csf2rbtm1Mur
Targeted Allele Detail
Summary
Symbol: Csf2rbtm1Mur
Name: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); targeted mutation 1, Richard Murray
MGI ID: MGI:2181261
Synonyms: betac-, betac mutant
Gene: Csf2rb  Location: Chr15:78210000-78235201 bp, + strand  Genetic Position: Chr15, 37.36 cM
Alliance: Csf2rbtm1Mur page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:24122
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 was replaced by a neomycin cassette via homologous recombination. The deleted region encodes the third and fourth cysteine residues in the first repeat of the conserved motif of cytokine receptors. FACS analysis of bone marrow cells isolated from homozygous mutant mice showed a lack of a functional receptor. Additional FACS analysis showed that expression of the homologous protein, Csf3rb2, was intact. (J:24122)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csf2rb Mutation:  47 strains or lines available
References
Original:  J:24122 Nishinakamura R, et al., Mice deficient for the IL-3/GM-CSF/IL-5 beta c receptor exhibit lung pathology and impaired immune response, while beta IL3 receptor-deficient mice are normal. Immunity. 1995 Mar;2(3):211-22
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory