Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Csf1rtm1Ers
Name:	colony stimulating factor 1 receptor; targeted mutation 1, E Richard Stanley
MGI ID:	MGI:2181194
Synonyms:	Csf1r-, fmsEGFP
Gene:	Csf1r  Location: Chr18:61238644-61264211 bp, + strand  Genetic Position: Chr18, 34.41 cM, cytoband D
Alliance:	Csf1rtm1Ers page

Germline Transmission:	Earliest citation of germline transmission: J:73663
Parent Cell Line:	ESVJ-1182 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: Exon 3 was disrupted by the insertion of an in-frame cassette containing a humanized green fluorescent protein sequence and a neomycin resistance gene. While annulment of the allele in mutant mice was indicated by Western blot analysis of bone-marrow derived macrophages, expression of the green fluorescent protein could not be detected by fluorescence microscopy or flow cytometry. (J:73663)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

16 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Csf1r Mutation:	63 strains or lines available

Original:	J:73663 Dai XM, et al., Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood. 2002 Jan 1;99(1):111-20
All:	29 reference(s)