Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bcar1tm1Hhi
Name:	breast cancer anti-estrogen resistance 1; targeted mutation 1, Hisamaru Hirai
MGI ID:	MGI:2181166
Synonyms:	Cas-deficient
Gene:	Bcar1  Location: Chr8:112437106-112470441 bp, - strand  Genetic Position: Chr8, 57.98 cM, cytoband D3
Alliance:	Bcar1tm1Hhi page

Germline Transmission:	Earliest citation of germline transmission: J:48967
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin selection cassette disrupts exon 2, which encodes the SH3 domain. Western blot analysis showed an absence of encoded protein in homozygous mutant embryos. (J:48967, J:138258)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bcar1 Mutation:	26 strains or lines available

Original:	J:48967 Honda H, et al., Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas [see comments]. Nat Genet. 1998 Aug;19(4):361-5
All:	2 reference(s)