Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cntn2tm1Fuka
Name:	contactin 2; targeted mutation 1, Fumihiko Fukamauchi
MGI ID:	MGI:2181052
Synonyms:	TAG-1 (-)
Gene:	Cntn2  Location: Chr1:132437163-132470989 bp, - strand  Genetic Position: Chr1, 57.42 cM
Alliance:	Cntn2tm1Fuka page

Germline Transmission:	Earliest citation of germline transmission: J:67556
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The region between exon 2 and 5, encoding the translational start codon through the first Ig-like domain, was replaced by a neomycin selection cassette. Western blot analysis using antibodies raised against the amino and carboxyl terminals showed an absence of encoded protein in homozygous mutant mice. (J:67556)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

28 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cntn2 Mutation:	53 strains or lines available

Original:	J:67556 Fukamauchi F, et al., TAG-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus. Biochem Biophys Res Commun. 2001 Feb 16;281(1):220-6
All:	14 reference(s)