Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cntftm1Gdy
Name:	ciliary neurotrophic factor; targeted mutation 1, George D Yancopoulos
MGI ID:	MGI:2181048
Synonyms:	CNTF-
Gene:	Cntf  Location: Chr19:12741024-12742996 bp, - strand  Genetic Position: Chr19, 8.73 cM
Alliance:	Cntftm1Gdy page

Germline Transmission:	Earliest citation of germline transmission: J:29357
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced exons 1 and 2. Western blot analysis showed an absence of encdoded protein in sciatic nerve extracts from homozygous mutant mice. (J:29357)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cntf Mutation:	13 strains or lines available

Original:	J:29357 DeChiara TM, et al., Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell. 1995 Oct 20;83(2):313-22
All:	2 reference(s)