Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cdc45tm1Dta
Name:	cell division cycle 45; targeted mutation 1, Anindya Dutta
MGI ID:	MGI:2180780
Synonyms:	CDC45-
Gene:	Cdc45  Location: Chr16:18599197-18630737 bp, - strand  Genetic Position: Chr16, 11.63 cM
Alliance:	Cdc45tm1Dta page

Germline Transmission:	Earliest citation of germline transmission: J:70008
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection gene replaced exons 1 and 2, which encode the 199 amino-terminal residues. RT-PCR analysis of total RNA obtained from heterozygous mutant embryos showed that the level of normal transcript was approximately half of what was detected in wild-type embryos. (J:70008)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc45 Mutation:	43 strains or lines available

Original:	J:70008 Yoshida K, et al., Requirement of CDC45 for postimplantation mouse development. Mol Cell Biol. 2001 Jul;21(14):4598-603
All:	2 reference(s)