Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd22tm1Lam
Name:	CD22 antigen; targeted mutation 1, Marinus C Lamers
MGI ID:	MGI:2180698
Synonyms:	CD22-
Gene:	Cd22  Location: Chr7:30564829-30579767 bp, - strand  Genetic Position: Chr7, 19.26 cM
Alliance:	Cd22tm1Lam page

Germline Transmission:	Earliest citation of germline transmission: J:38644
Parent Cell Line:	BL/6-III (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 11, encoding the transmembrane domain, was disrupted by the insertion of a neomycin cassette. Flow cytometric analysis showed an absence of surface expression on splenocytes isolated from homozygous mutant mice. (J:38644)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd22 Mutation:	63 strains or lines available

Original:	J:38644 Nitschke L, et al., CD22 is a negative regulator of B-cell receptor signalling. Curr Biol. 1997 Feb 1;7(2):133-43
All:	26 reference(s)