Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cd19tm1Tft
Name:	CD19 antigen; targeted mutation 1, Thomas F Tedder
MGI ID:	MGI:2180685
Synonyms:	CD19-
Gene:	Cd19  Location: Chr7:126007622-126014061 bp, - strand  Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
Alliance:	Cd19tm1Tft page

Germline Transmission:	Earliest citation of germline transmission: J:27236
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 5 encoding the transmembrane domain and 7 of the 9 exons encoding cytoplamic domains were replaced with a neomycin cassette. In addition, the inserted neomycin gene introduced a stop codon. Immunohistochemical staining showed a lack of protein expression in the spleens of homozygous mutant mice. (J:27236, J:100523)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd19 Mutation:	56 strains or lines available

Original:	J:27236 Engel P, et al., Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity. 1995 Jul;3(1):39-50
All:	34 reference(s)