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Ccnd1tm1Dsn
Targeted Allele Detail
Summary
Symbol: Ccnd1tm1Dsn
Name: cyclin D1; targeted mutation 1, Clive Dickson
MGI ID: MGI:2180640
Synonyms: Ccnd1(-), cyclin D1-, Cyl-1-
Gene: Ccnd1  Location: Chr7:144483668-144493568 bp, - strand  Genetic Position: Chr7, 88.92 cM
Alliance: Ccnd1tm1Dsn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29258
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a PGK-neo cassette deleted 200 nucleotides of exon 1 encoding a portion of the LXCXE motif. Northern blot analysis revealed an absence of transcript in homozygous mutant mice. Protein expression was not detected by Western blot analyses of extracts from homozygous mutant kidney, lung, and seminal vesicle tissue. (J:29258)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccnd1 Mutation:  21 strains or lines available
References
Original:  J:29258 Fantl V, et al., Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes Dev. 1995 Oct 1;9(19):2364-72
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory