Cbltm1.1Hua
Targeted Allele Detail
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| Symbol: |
Cbltm1.1Hua |
| Name: |
Casitas B-lineage lymphoma; targeted mutation 1.1, Hua Gu |
| MGI ID: |
MGI:2180576 |
| Synonyms: |
c-cbl- |
| Gene: |
Cbl Location: Chr9:44054273-44145346 bp, - strand Genetic Position: Chr9, 24.72 cM
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| Alliance: |
Cbltm1.1Hua page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:51666
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: The transient expression of cre recombinase within ES cells resulted in the excision of a floxed region containing a neomycin gene and the exon containing nucleotides 681-837 of the published mouse cDNA sequence deposited in GenBank as X57111. The deletion introduced a frameshift mutation. RT-PCR analysis of total RNA extracts from homozygous mutant mice showed an absence of normal transcript. Western analysis using an antibody raised against the C-terminal failed to detect protein in homozygous mutant mice.
(J:51666)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Cbl Mutation: |
57 strains or lines available
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| Original: |
J:51666 Naramura M, et al., Altered thymic positive selection and intracellular signals in Cbl-deficient mice. Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15547-52 |
| All: |
33 reference(s) |
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Analysis Tools
