Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cblbtm1Pngr
Name:	Casitas B-lineage lymphoma b; targeted mutation 1, Josef M Penninger
MGI ID:	MGI:2180570
Synonyms:	Clb-b-
Gene:	Cblb  Location: Chr16:51851593-52028410 bp, + strand  Genetic Position: Chr16, 32.88 cM
Alliance:	Cblbtm1Pngr page

Germline Transmission:	Earliest citation of germline transmission: J:76896
Parent Cell Line:	E14K (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin cassette replaced the region encoding a portion of the tyrosine kinase-binding and RING finger domains, corresponding to amino acids 300 through 340 of the encoded protein. Western blot analysis showed an absence of protein expression in lymph nodes and splenocytes from homozygous mice. (J:76896)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Cblb Mutation:	56 strains or lines available

Original:	J:76896 Bachmaier K, et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 2000 Jan 13;403(6766):211-6
All:	37 reference(s)