Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacnb3tm1Hssh
Name:	calcium channel, voltage-dependent, beta 3 subunit; targeted mutation 1, Hee-Sup Shin
MGI ID:	MGI:2180537
Synonyms:	beta3-, Cavbeta3-
Gene:	Cacnb3  Location: Chr15:98528721-98542410 bp, + strand  Genetic Position: Chr15, 54.64 cM
Alliance:	Cacnb3tm1Hssh page

Germline Transmission:	Earliest citation of germline transmission: J:50152
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection gene replaced the entire coding region downstream of exon 1. Northern analysis showed a lack of transcript in the brains of homozygous mutant mice. (J:50152)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacnb3 Mutation:	24 strains or lines available

Original:	J:50152 Namkung Y, et al., Targeted disruption of the Ca2+ channel beta3 subunit reduces N- and L-type Ca2+ channel activity and alters the voltage-dependent activation of P/Q-type Ca2+ channels in neurons. Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):12010-5
All:	6 reference(s)