Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il5ratm1Ktk
Name:	interleukin 5 receptor, alpha; targeted mutation 1, Kiyoshi Takatsu
MGI ID:	MGI:2180501
Synonyms:	IL-5Ralpha-
Gene:	Il5ra  Location: Chr6:106687336-106725998 bp, - strand  Genetic Position: Chr6, 49.19 cM
Alliance:	Il5ratm1Ktk page

Germline Transmission:	Earliest citation of germline transmission: J:33140
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A stop codon was introduced into exon 5 and a neo cassette was inserted into exon 6 via homologous recombination. The neo insertion disrupts 4 cysteine residues that are conserved within the cytokine receptor family. Absence of gene expression was verified by flow cytometry analysis of resting peritoneal cells from homozygous mutant animals. (J:33140)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il5ra Mutation:	36 strains or lines available

Original:	J:33140 Yoshida T, et al., Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Immunity. 1996 May;4(5):483-94
All:	12 reference(s)