Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Bace1tm1Vas
Name:	beta-site APP cleaving enzyme 1; targeted mutation 1, Robert Vassar
MGI ID:	MGI:2180468
Synonyms:	BACE1-
Gene:	Bace1  Location: Chr9:45749878-45775694 bp, + strand  Genetic Position: Chr9, 25.22 cM
Alliance:	Bace1tm1Vas page

Germline Transmission:	Earliest citation of germline transmission: J:67736
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene replaced a 2.0 kb region containing exon 1, which encodes amino acids 1 through 87. Expressed protein was undetectable in the brains of homozygous mice through immunoblotting analysis. (J:67736)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bace1 Mutation:	27 strains or lines available

Original:	J:67736 Luo Y, et al., Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci. 2001 Mar;4(3):231-2
All:	13 reference(s)