Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tnp2tm1Mzh
Name:	transition protein 2; targeted mutation 1, Ming Zhao
MGI ID:	MGI:2180358
Synonyms:	Tnp2-
Gene:	Tnp2  Location: Chr16:10605799-10606519 bp, - strand  Genetic Position: Chr16, 5.83 cM, cytoband B1-B3
Alliance:	Tnp2tm1Mzh page

Germline Transmission:	Earliest citation of germline transmission: J:72107
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire gene was replaced with a neo cassette flanked by loxP sites via homologous recombination. Northern and Western blot analysis verified the absence of gene expression in testes of homozygous mutant animals. (J:72107)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnp2 Mutation:	5 strains or lines available

Original:	J:72107 Zhao M, et al., Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice. Mol Cell Biol. 2001 Nov;21(21):7243-55
All:	4 reference(s)