Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacna1etm1Rjml
Name:	calcium channel, voltage-dependent, R type, alpha 1E subunit; targeted mutation 1, Richard J Miller
MGI ID:	MGI:2180170
Gene:	Cacna1e  Location: Chr1:154266477-154760247 bp, - strand  Genetic Position: Chr1, 66.14 cM
Alliance:	Cacna1etm1Rjml page

Germline Transmission:	Earliest citation of germline transmission: J:66144
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 4-8 encoding the pore-lining domain and neighboring transmembrane domains were replaced with a neo-URA3 cassette via homologous recombination. Western blot of brain extract from homozygous mutant animals confirmed the absence of protein product. Northern blot analysis also failed to detect gene expression. (J:66144)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1e Mutation:	102 strains or lines available

Original:	J:66144 Wilson SM, et al., The status of voltage-dependent calcium channels in alpha 1E knock-Out mice. J Neurosci. 2000 Dec 1;20(23):8566-71
All:	6 reference(s)