Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stambptm1Sug
Name:	STAM binding protein; targeted mutation 1, Kazuo Sugamura
MGI ID:	MGI:2180168
Synonyms:	AMSH-/-
Gene:	Stambp  Location: Chr6:83520193-83549711 bp, - strand  Genetic Position: Chr6, 35.94 cM
Alliance:	Stambptm1Sug page

Germline Transmission:	Earliest citation of germline transmission: J:72940
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A single loxP site was inserted 5' to exon 3 and a neomycin selection cassette followed by a loxP site was inserted 3' to exon 4 through homologous recombination. The transient expression of Cre-recombinase within the targeted ES cells resulted in the excision of exons 3 and 4 and the neomycin selection gene. Northern blot analysis of total RNA isolated from the brains of homozygous animals demonstrated that no detectable transcript was expressed from this allele. (J:72940)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stambp Mutation:	23 strains or lines available

Original:	J:72940 Ishii N, et al., Loss of Neurons in the Hippocampus and Cerebral Cortex of AMSH-Deficient Mice. Mol Cell Biol. 2001 Dec;21(24):8626-37
All:	2 reference(s)