Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Cacng1tm1Vfz
Name:	calcium channel, voltage-dependent, gamma subunit 1; targeted mutation 1, Veit Flockerzi
MGI ID:	MGI:2180153
Synonyms:	gamma-, gamma1-
Gene:	Cacng1  Location: Chr11:107594044-107607302 bp, - strand  Genetic Position: Chr11, 70.29 cM, cytoband E1
Alliance:	Cacng1tm1Vfz page

Germline Transmission:	Earliest citation of germline transmission: J:62133
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The 3' portion of exon 1 and adjacent splice donor site were replaced with a neo resistance cassette via homologous recombination. Absence of gene expression was confirmed by Northern and Western blot analysis of skeletal muscle from homozygous mutant animals. In addition, RT-PCR failed to amplify the complete coding region of the gene as well as portions of the transcript corresponding to exons 2, 3, and 4. (J:62133)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacng1 Mutation:	14 strains or lines available

Original:	J:62133 Freise D, et al., Absence of the gamma subunit of the skeletal muscle dihydropyridine receptor increases L-type Ca2+ currents and alters channel inactivation properties. J Biol Chem. 2000 May 12;275(19):14476-81
All:	4 reference(s)