Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pzptm1Vln
Name:	PZP, alpha-2-macroglobulin like; targeted mutation 1, Fred Van Leuven
MGI ID:	MGI:2180117
Synonyms:	MAM-
Gene:	Pzp  Location: Chr6:128460530-128503683 bp, - strand  Genetic Position: Chr6, 63.02 cM, cytoband F1-G3
Alliance:	Pzptm1Vln page

Germline Transmission:	Earliest citation of germline transmission: J:28328
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A construct was created by replacing 0.7-kb of intron 17 with PKC-hygro. Northern analysis of RNA isolated from the livers of homozygous mice showed an absence of transcript. Rocket immunoelectrophoresis also showed no expression. (J:28328)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	62 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pzp Mutation:	79 strains or lines available

Original:	J:28328 Umans L, et al., Targeted inactivation of the mouse alpha 2-macroglobulin gene. J Biol Chem. 1995 Aug 25;270(34):19778-85
All:	7 reference(s)