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Xrcc5tm1Dbr
Targeted Allele Detail
Summary
Symbol: Xrcc5tm1Dbr
Name: X-ray repair complementing defective repair in Chinese hamster cells 5; targeted mutation 1, David B Roth
MGI ID: MGI:2179987
Synonyms: Ku80-, Ku86-, xrcc5-, xrcc5M1
Gene: Xrcc5  Location: Chr1:72346586-72434111 bp, + strand  Genetic Position: Chr1, 36.5 cM, cytoband E
Alliance: Xrcc5tm1Dbr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34834
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details6 kb of this gene encoding amino acids 229-313 were replaced with a PGK-puro cassette via homologous recombination resulting in a frameshift after residue 313 and deleting 69% of the protein product. Northern blot analysis and RT-PCR of embryonic fibroblasts from homozygous mutants did not detect gene transcript. (J:34834)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 3 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Xrcc5tm1Dbr
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xrcc5 Mutation:  70 strains or lines available
References
Original:  J:34834 Zhu C, et al., Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell. 1996 Aug 9;86(3):379-89
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory