Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Synj1tm1Pdc
Name:	synaptojanin 1; targeted mutation 1, Pietro De Camilli
MGI ID:	MGI:2179801
Gene:	Synj1  Location: Chr16:90732980-90808196 bp, - strand  Genetic Position: Chr16, 52.18 cM, cytoband C3-C4
Alliance:	Synj1tm1Pdc page

Germline Transmission:	Earliest citation of germline transmission: J:58087
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing part of exon 1 and part of intron 1. Western blot analysis on brain tissue of homozygous mice demonstrated that no detectable protein was expressed from this allele. (J:58087)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Synj1 Mutation:	71 strains or lines available

Original:	J:58087 Cremona O, et al., Essential role of phosphoinositide metabolism in synaptic vesicle recycling. Cell. 1999 Oct 15;99(2):179-88
All:	16 reference(s)