Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Map3k1tm1Glj
Name:	mitogen-activated protein kinase kinase kinase 1; targeted mutation 1, Gary L Johnson
MGI ID:	MGI:2179711
Synonyms:	MEKK1 -
Gene:	Map3k1  Location: Chr13:111882962-111945527 bp, - strand  Genetic Position: Chr13, 63.36 cM
Alliance:	Map3k1tm1Glj page

Germline Transmission:	Earliest citation of germline transmission: J:62909
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance gene in the antisense orientation replaced 132 codons, including the ATG start site in exon 1. (J:62909)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Map3k1 Mutation:	62 strains or lines available

Original:	J:62909 Yujiri T, et al., MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7272-7
All:	7 reference(s)