Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Tnfsf10tm1Mjs
Name:	tumor necrosis factor (ligand) superfamily, member 10; targeted mutation 1, Mark J Smyth
MGI ID:	MGI:2179709
Synonyms:	Tnfsf10-, TRAIL-
Gene:	Tnfsf10  Location: Chr3:27371226-27393814 bp, + strand  Genetic Position: Chr3, 10.82 cM, cytoband A3
Alliance:	Tnfsf10tm1Mjs page

Germline Transmission:	Earliest citation of germline transmission: J:73948
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced sequences between nucleotides 274 and 371. Flow cytometry experiments on liver mononucleocytes and natural killer cells confirmed that no detectable protein was present on the cell surface. (J:73948)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Tnfsf10tm1Mjs

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfsf10 Mutation:	24 strains or lines available

Original:	J:73948 Cretney E, et al., Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice. J Immunol. 2002 Feb 1;168(3):1356-61
All:	43 reference(s)