Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vgftm1Srjs
Name:	VGF nerve growth factor inducible; targeted mutation 1, Stephan R J Salton
MGI ID:	MGI:2179681
Synonyms:	Vgf-
Gene:	Vgf  Location: Chr5:137055246-137062205 bp, + strand  Genetic Position: Chr5, 76.13 cM
Alliance:	Vgftm1Srjs page

Germline Transmission:	Earliest citation of germline transmission: J:56499
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire Vgf coding sequence was replaced with the PGK-driven neomycin cassette. The absence of transcript and protein as a result of the targetting event was demonstrated through Northern and Western analysis, respectively. (J:56499)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vgf Mutation:	26 strains or lines available

Original:	J:56499 Hahm S, et al., Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance. Neuron. 1999 Jul;23(3):537-48
All:	6 reference(s)