Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gata4tm1Eno
Name:	GATA binding protein 4; targeted mutation 1, Eric N Olson
MGI ID:	MGI:2179443
Synonyms:	GATA4-
Gene:	Gata4  Location: Chr14:63436371-63509141 bp, - strand  Genetic Position: Chr14, 33.24 cM
Alliance:	Gata4tm1Eno page

Germline Transmission:	Earliest citation of germline transmission: J:40145
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons containing the 2 DNA-binding zinc finger domains were replaced with a neomycin cassette via homologous recombination. RT-PCR analysis of homozygous mutant embryos did not detect wild-type transcript. (J:40145)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	59 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:	36 strains or lines available

Original:	J:40145 Molkentin JD, et al., Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev. 1997 APR 15;11(8):1061-1072
All:	17 reference(s)